Bone marrow matures

The Immune System in Health and Disease. The greater part of lymphocyte development in mammals occurs in the specialized environments of the central lymphoid organs—the bone marrow and the liver in the fetus for B cells and the thymus for T cells.

It is well established that Ly6C hi monocytes develop from common monocyte progenitors cMoPs and reside in the bone marrow BM until they are mobilized into the circulation. In our study, we found that BM Ly6C hi monocytes are not a homogenous population, as current data would suggest.

Bone marrow is found in the medullary cavities — the centres of bones.

A comparative study of immature and mature bone marrow-derived dendritic cells BMDCs was first performed through an atomic force microscope AFM to clarify differences of their nanostructure and adhesion force. AFM images revealed that the immature BMDCs treated by granulocyte macrophage-colony stimulating factor plus IL-4 mainly appeared round with smooth surface, whereas the mature BMDCs induced by lipopolysaccharide displayed an irregular shape with numerous pseudopodia or lamellapodia and ruffles on the cell membrane besides becoming larger, flatter, and longer.

Bone marrow: Function, diseases, transplants, and donation

Dendritic cells DCs are professional antigen-presenting cells of the immune system and can be generated in vitro from bone-marrow cells.

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